International Journal of Pharma Research 5(3):51-58
نویسندگان
چکیده
Regulation of pH is critical for physiological processes. Maintenance of acid-base homeostasis is tightly regulated by the renal and respiratory systems. However, fluctuations in extracellular pH are also sensed by other organ systems. Ion transporter activity to modify the amount of acid (H+ and CO2) and bicarbonate HCO3 is therefore actively maintained within the kidney and lung. This review describes acid-base disorders (acidosis and alkalosis) and highlights the importance of pH sensors and ion transporters that may be potential therapeutic targets for treatment of acid-base disorders. Specifically, the renal pH sensors prolinerich tyrosine kinase-2 (Pyk2) and G-protein coupled receptor-4 (GPR4) are discussed here.
منابع مشابه
Translatability Assessment and Linguistic Validation of The Patient-Reported Outcome Instrument for Irritable Bowel Syndrome With Diarrhea (Ibs-D Pro).
1Astellas Pharma Global Development, 1 Astellas Way, Northbrook, IL, USA; 2Pharmerit International, 275 Grove Street, Newton, MA, USA (formerly of Adelphi Values, Boston, MA, USA); 3TransPerfect, 100 High Street, Boston, MA, USA; 4Astellas Pharma Inc., 2-5-1, Nihonbashi-Honcho, Chuo-ku, Tokyo 103-8411, Japan; 5Adelphi Values, Adelphi Mill, Grimshaw Lane, Bollington, Cheshire, UK, 6Adelphi Value...
متن کاملDrug-resistant gene of blaOXA-23, blaOXA-24, blaOXA-51 and blaOXA-58 in Acinetobacter baumannii.
We distinguished the four alleles of OXA subgroups from 339 strains of Acinetobacter baumannii using Polymerase Chain Reaction, and investigated distributions of OXA subgroups in clinical isolated strains. A total of 196 Acinetobacter baumannii were isolated from the Central Hospital of Zhumadian between 2010 and 2014. Amplification of OXA genes, blaOXA-23, blaOXA-24, blaOXA-51 and blaOXA-58, w...
متن کاملBRIC Health Systems and Big Pharma: A Challenge for Health Policy and Management
BRIC nations – Brazil, Russia, India, and China – represent 40% of the world’s population, including a growing aging population and middle class with an increasing prevalence of chronic disease. Their healthcare systems increasingly rely on prescription drugs, but they differ from most other healthcare systems because healthcare expenditures in BRIC nations have exhibited the highest revenue gr...
متن کاملInternational Journal of Pharma Research 5(8):40-42
Tuberculosis (TB) is a serious threat for public health and major infectious cause of mortality worldwide: according to the WHO, international death toll due to Mycobacterium tuberculosis infection is approximately 2 million people each year, and about 8 million new infection cases are registered annually.
متن کاملInternational Journal of Pharma Research 5(8):43-46
Determining whether a drug reaches its intended target is vital for drug development. Commonly, liquid chromatography tandem mass spectrometry (LC-MS/MS) is used to to determine the concentration of drug or its metabolites in homogenized tissues or from blood.
متن کامل